Title: Development and Validation of an In-House Optical Reader for Quantitative Point-of-Care Testing of Fibrinogen
Introduction:
Post-partum hemorrhage (PPH) is a major cause of maternal morbidity and mortality worldwide. Timely detection and management of fibrinogen levels, a critical coagulation factor, is crucial in effectively managing PPH. Current laboratory-based methods for measuring fibrinogen levels are time-consuming and require specialized equipment, making them impractical for point-of-care testing. This research proposal aims to develop and validate a novel quantitative point-of-care test for fibrinogen using an in-house optical reader, enabling rapid and accurate measurement in a wide range of clinical settings, including PPH.
Objectives:
Develop a novel point-of-care test for fibrinogen utilizing a portable and affordable optical reader.
Validate the performance and accuracy of the test using a wide range of clinical samples.
Assess the feasibility and usability of the test in various clinical settings, including PPH scenarios.
Compare the results obtained from the point-of-care test with standard laboratory methods for fibrinogen measurement.
Evaluate the impact of the point-of-care test on clinical decision-making and patient outcomes in the context of PPH management.
Methodology:
a) Test Development:
Design and optimize a fibrinogen-specific assay suitable for point-of-care testing.
Develop a user-friendly cartridge or test strip format for sample analysis.
Integrate the assay with an in-house optical reader edit.
Introduction:
Post-partum hemorrhage (PPH) is a major cause of maternal morbidity and mortality worldwide. Timely detection and management of fibrinogen levels, a critical coagulation factor, is crucial in effectively managing PPH. Current laboratory-based methods for measuring fibrinogen levels are time-consuming and require specialized equipment, making them impractical for point-of-care testing. This research proposal aims to develop and validate a novel quantitative point-of-care test for fibrinogen using an in-house optical reader, enabling rapid and accurate measurement in a wide range of clinical settings, including PPH.
Objectives:
Develop a novel point-of-care test for fibrinogen utilizing a portable and affordable optical reader.
Validate the performance and accuracy of the test using a wide range of clinical samples.
Assess the feasibility and usability of the test in various clinical settings, including PPH scenarios.
Compare the results obtained from the point-of-care test with standard laboratory methods for fibrinogen measurement.
Evaluate the impact of the point-of-care test on clinical decision-making and patient outcomes in the context of PPH management.
Methodology:
a) Test Development:
Design and optimize a fibrinogen-specific assay suitable for point-of-care testing.
Develop a user-friendly cartridge or test strip format for sample analysis.
Integrate the assay with an in-house optical reader edit.